[Role of omalizumab in the management of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis].

نویسندگان

  • Isabel Delgado Pecellín
  • Esther Quintana Gallego
  • Celeste Pedregal Solano
  • Carmen Calero Acuña
چکیده

1. Björnsson E, Talwalkar J, Treeprasertsuk S, Kamath PS, Takahasi N, Sanderson S, et al. Drug-induced autoimmune hepatitis: clinical characteristic and prognosis. Hepatology. 2010;51:2040–8. 2. Alla V, Abraham J, Siddiqui J, Raina D, Wu GY, Chalasani NP, et al. Autoimmune hepatitis triggered by statins. J Clin Gastroenterol. 2006;40:757–61. 3. Czaja AJ. Drug-induced autoimmune-like hepatitis. Dig Dis Sci. 2011;56:958–76. 4. Lucena MI, García-Martín E, Andrade RJ, Martínez C, Stephens C. Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug-induced liver injury. Hepatology. 2010;52:303–12. 5. Rockey DC, Seeff LB, Rochon J, Freston J, Chalasani N, Bonacini M, et al. Causality assessment in drug-induced liver injury using a structured expert opinion process: comparison to the Roussel-Uclaf causality assessment method. Hepatology. 2010;51:2117–26. 6. Björnsson E, Davidsdottir L. The long-term follow-up after idiosyncratic druginduced liver injury with jaundice. J Hepatol. 2009;50:511–7. 7. Aithal PG, Day CP. The natural history of histologically proved drug induced liver disease. Gut. 1999;44:731–5. 8. Ohmoto K, Yamamoto S. Drug-induced liver injury associated with antinuclear antibodies. Scand J Gastroenterol. 2002;11:1345–6.

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Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody.

Allergic bronchopulmonary aspergillosis (ABPA) can cause severe worsening of the respiratory condition in patients with cystic fibrosis. Treatment can result in steroid dependency and serious adverse events. A dramatic and rapid improvement of respiratory symptoms and lung function after a single dose of anti-IgE antibody (omalizumab) in a 12-year-old girl with cystic fibrosis and ABPA is descr...

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A case report of ABPA, cystic fibrosis and asthma treated with omalizumab

Introduction In Canada the use of Omalizumab is restricted to patients with moderate to severe allergic asthma. However there are some cases reports showing its effectiveness in other conditions like chronic urticaria, ABPA and patients with nasal polyps and asthma. Although there are also reports of using omalizumab in patients with cystic fibrosis and ABPA, there are not controlled trials con...

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Steroid sparing effect of omalizumab in seropositive allergic bronchopulmonary aspergillosis

BACKGROUND Allergic bronchopulmonary aspergillosis (ABPA) is a common serious hypersensitivity reaction to airway colonization with Aspergillus in patients with asthma or cystic fibrosis. While steroids are effective in controlling the respiratory symptoms of ABPA, they have many side effects that make them undesirable for long term use. Antifungals have been used to reduce dependency on system...

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Allergic bronchopulmonary aspergillosis treated successfully for one year with omalizumab

BACKGROUND Current therapy for allergic bronchopulmonary aspergillosis (ABPA) uses oral corticosteroids, exposing patients to the adverse effects of these agents. There are reports of the steroid-sparing effect of anti-IgE therapy with omalizumab for ABPA in patients with cystic fibrosis (CF), but there is little information on its efficacy against ABPA in patients with bronchial asthma without...

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Anti IgE antibody as treatment of allergic bronchopulmonary aspergillosis in a patient with cystic fibrosis.

Allergic bronchopulmonary aspergillosis (ABPA) occurs in 7-9% of patients with cystic fibrosis (CF) and causes a worsening of lung function and respiratory symptoms. Standard treatment of ABPA consists of oral steroids; however, higher corticosteroid therapy associated to antifungal agent (itraconazole) long-term treatments are often required to reduce respiratory exacerbations and to prevent p...

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Allergic bronchopulmonary aspergillosis treated successfully with omalizumab.

Allergic bronchopulmonary aspergillosis (ABPA) is caused by a hypersensitivity response of type 2 T helper (Th2) lymphocytes to antigens, mostly Aspergillus fumigatus (A. fumigatus).1 This abnormal host response to A. fumigatus in a subset of patients with asthma or cystic fibrosis (CF) is likely due to genetic susceptibility that predisposes patients to the risk of developing ABPA. This is cha...

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عنوان ژورنال:
  • Medicina clinica

دوره 144 4  شماره 

صفحات  -

تاریخ انتشار 2015